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10.1002/epi4.12371 67

HOT-286 (BU063)

Neuropsychopharmacology 38 , 2338 (2013)

10.1016/j.redox.2016.12.011 Redox Biol

Abstract In schizophrenia patients, glutathione dysregulation at the gene, protein and functional levels, leads to N -methyl-D-aspartate (NMDA) receptor hypofunction

Beginning at the rarest variants, the average human carries 10100 novel coding variants that are absent in other participants in large human genetic data sets (gnomAD being the largest) [62], though new estimates suggest this number could be even higher [63]