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PloS One 17, e0262140

Denoyer, D

Research suggests it has a relatively mild safety profile, but long-term safety studies are still limited

vWF is stored in WeibelPalade bodies within endothelial cells and is rapidly secreted into the circulation following endothelial activation or damage, where it mediates platelet adhesion and forms high-molecular-weight multimers associated with pathological thrombosis (Lodigiani et al., 2020)

Since 2010, it has technically remained the only truly FDA-approved treatment specifically indicated for the treatment of chronic migraine prevention, up until Qulipta (Atogepant) became the first and only pill to receive FDA approval for chronic migraine in 2023