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As mice age, such protective effect may be lost due to higher pathology burden

doi: 10.1016/j.cmet.2016.11.004 22 HandelsmanD

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DeLuna, A., Avendano, A., Riego, L

Furthermore, increases in oxidative stress and nitrosative stress accompanied by an increase in total SOD activity have been observed in the muscles of COPD patients while they are at rest [16]