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The original clinical development, by the Canadian biotech ConjuChem, was discontinued, and there is no validated disease endpoint for either version

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Near-infrared fluorescence lymphatic imaging (NIRFLI) has added additional techniques to MLD including the Fill and Flush method (122)

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Activated Th1 and Th17 cells produce inflammatory products and cytokines that disrupt myelin and axons and activate retained microglia, which in turn generate inflammatory cells that attract more inflammatory cells to the central nervous system (CNS) and perpetuate the inflammatory cascade ( in vitro and in mouse EAE (82)