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Besides targeting ERK, DUSP14 directly inactivates TAB1 by dephosphorylating its Ser438 residue, inhibiting the TCR-stimulated activation of TAK1 and downstream JNK/IKK in human Jurkat T cells upon TCR signaling (Fig

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This effect was not seen in the normal-weight rats

drug exposure (area under the curve and peak concentration) was similar in those with cirrhosis and healthy participants, with the 90% confidence intervals for the adjusted ratios spanning 1

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