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Additionally, SGLT2 inhibitors have been shown to be beneficial in the prevention of AKI in two different randomized, placebo-controlled trials: Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) and Dapagliflozin Effect on Cardiovascular Events-Thrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) (137, 138)

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CIRI: Cerebral ischemia and reperfusion injury PGC1: Peroxisome proliferator-activated receptor-gamma coactivator MS: Multiple sclerosis BBB: Blood-brain barrier DHLA: Dihydrolipoic acid References Park S, Karunakaran U, Ho Jeoung N, Jeon JH, Lee IK (2014) Physiological effect and therapeutic application of alpha lipoic acid

The Executive Order also authorizes the states Water Resources Control Board to implement restrictions on individual users to meet overall water savings objectives