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In the UK, vitamin B12 levels below 150 pmol/L are usually considered deficient and typically require treatment

In a 2024 case study, researchers reported one instance of mixed-state bipolar disorder that may have been triggered by vitamin B12 overdose

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P = 0.02] were low-risk factors for G2G4 anemia (Supplement Fig

These include men who follow strict vegetarian or vegan diets (especially for B12), those with chronic digestive issues that affect nutrient absorption, and men over 50 whose absorption naturally decreases with age