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Description

Combined nicotinamide N-methyltransferase inhibition and lean-diet substitution reduces body weight and liver fat in obese mice

The risk of chronic diseases and death increases

Sources & Research 1

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Understanding these energy metabolism effects is relevant to research on obesity and metabolic health

By selectively inhibiting NNMT , 5-Amino-1MQ can reduce the methylation of nicotinamide, leading to increased intracellular NAD availability and enhanced metabolic activity