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Brief report: intraarticular sprifermin not only increases cartilage thickness, but also reduces cartilage loss: location-independent post hoc analysis using magnetic resonance imaging

The trial evaluated multiple dosing cohorts with an escalation schedule designed to minimize gastrointestinal side effects during the initial weeks of treatment: Key Observations From Retatrutide Dosage Data Dose-dependent response Weight reduction increased in a clear dose-dependent pattern across all cohorts

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