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doi: 10.2147/vhrm.s1991

Estrella J, Correa A, Swisher SG , Ajani J, Rashid A, Hofstetter WL, Maru D

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The complexity of signaling pathways and systemic effects often obscures the precise mechanisms and causal relations

Pb 2+ also activates the synthesis and secretion of the proinflammatory cytokine IL-8 through a nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent mechanism involved in the synthesis of xenobiotic-metabolizing enzymes (Metryka et al