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Evidence-Based Complementary and Alternative Medicine , 2022 , 113

Consume DAO-enhancing foods: Some foods, like fresh vegetables, fruits, and lean proteins, can support histamine metabolism

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[DOI] [PMC free article] [PubMed] [Google Scholar] 5.El-Hafidi M., Franco M., Ramrez A.R., Sosa J.S., Flores J.A.P., Acosta O.L., Salgado M.C., Cardoso-Saldaa G

Here, we show that replacement of a single amino acid at position 973, just distal to the NPEY motif in the intracellular juxtamembrane region, from leucine, which is highly conserved in IRs, to phenylalanine, the highly conserved homologous residue in IGF1Rs, resulted in decreased IRS-1/PI3K/Akt/mTORC1 signaling and increased Shc/Gab1/MAPK cell cycle signaling