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Annuzzi G, Rivellese AA, Bozzetto L, et al

doi:10.1155/2017/3050895 Olas B

10.1007/s12011-012-9530-6 90

Apoptosis operates through two distinct pathways: the intrinsic pathway, which is dependent on internal signaling, primarily regulated by the BCL-2 family of proteins and involves mitochondria interactions, and the extrinsic pathway, which is dependent of external signaling and independent of BCL-2 and mitochondrial involvement (Jan and Chaudhry, 2019)