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Alpha-lipoic acid (ALA) is an amphipathic antioxidant, which functions as a co-factor for complex multi-enzymes, such as pyruvate dehydrogenase and ketoglutarate dehydrogenase 49,50

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In this case, reorganization of cytoskeleton can occur through direct oxidation and disruption of the cytoskeleton proteins leading to structural changes, or through inhibition of actin polymerization by interference with the signaling pathways involved in this process (Mittal et al., 2014)

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