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Herein, we summarize various aspects of T-cell biological characteristics related to CAR-T cell therapy outcomes, including exhaustion, memory differentiation, senescence, T-cell subsets, metabolism, and T-cell receptor (TCR) repertoire (Fig

The bodys ability to produce glutathione depends on the availability of its amino acid building blocks, particularly cysteine, which is often the rate-limiting factor in glutathione synthesis

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doi:10.1096/fj.201801533R