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Research has revealed that the complex modulates the expression of over 4,000 mammalian genes, with particularly pronounced effects on genes involved in tissue repair, antioxidant defense, and inflammatory resolution

79 Immune cells from people with fibromyalgia have demonstrated signs of mitochondrial dysfunction including low CoQ10 levels, increased oxidative stress, reduced mitochondrial capacity to generate energy, and increased removal of dysfunctional mitochondria

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16, 21 Therefore, we have undertaken extensive studies to determine the potential for BSO to enhance the anti-myeloma activity of L-PAM at clinically achievable doses using in vitro (cell lines and fresh MM explants) and in vivo MM xenografts to determine if BSO+L-PAM warrants clinical trials in MM