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MPP + treatment significantly reduces TIGAR expression in HT22 cells, downregulates NADPH, GPX4, and GSH levels, upregulates GSSG levels and the GSSG/GSH ratio, decreases adenosine triphosphate (ATP) production, and promotes neuronal ferroptosis, iron-dependent lipid peroxidation, and mitochondrial dysfunction, thereby exacerbating neuronal cytotoxicity

However, it is not approved for human consumption

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PubMed , doi:10.1016/j.nut.2017.03.007

When doing a similar comparison with the 140 genes induced by superoxide/H 2 O 2 detected in the same study [124], 70 % (98 genes) were also induced by allyl-ITC at one of the three time points

As a stand-alone agent, cysteamine received a strong recommendation as it has a beneficial efficacy and safety profile