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Mitochondrial p53 is apparently linked to intrinsic apoptosis signaling, so this relocalization is posited to increase susceptibility to apoptosis specifically in senescent cells

In the same year, a related report in the International Journal of Obesity described fat-oxidation and body-weight-associated changes in obese mice from chronic treatment with a modified C-terminal hGH fragment, notably without inducing hyperglycemia or reducing insulin secretion [6]