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MitochondrialDirected Therapies: Promising Results From CellBased Assays A newer approach being evaluated in the field of cyanide toxicology is subcellular targeting of antidotes, leveraging a class of succinate prodrugs that is being developed for patients with genetic complex I deficiency [91]

Furthermore, the oral bioavailability of the optimized formulation was significantly higher than that of the Onon capsule, showing approximately 2.5- and 3.3-fold increases in AUC 0 12 h and C max , respectively

J Chromatogr B Anal Technol Biomed Life Sci 964:191194

Hatano A, Okada J, Washio T, Hisada T, Sugiura S (2013) Mitochondrial colocalization with Ca2+ release sites is crucial to cardiac metabolism

Chem Eng J Apr

This model often demonstrates morphological changes of the entire colonic wall that shows visceral hypersensitivity similar to human IBS symptoms (Traini et al., 2016)