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Inject 0.5 mL intramuscularly in the newborn's thigh (vastus lateralis)

These authors contributed equally: Khalishah Yusri, Sandra Jose, Karen S

doi:10.1210/endo.141.11.7873

Exercise raised skeletal-muscle MOTS-c roughly 12-fold in that work

In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)