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Bearing in mind the aforementioned caveat that the tobacco remedy may not be equated to nicotine alone, the choice of route of administration is interesting, given absorption of nicotine via the oral route is subjected to first-pass metabolism, with only a fraction of ingested material reaching the brain ( via smoking would be more effective in terms of nicotine levels, which suggests the maximization thereof not to be the main objective or priority of this tobacco therapy, nor the minimization of symptoms of intoxication like vomiting

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Am J Respir Crit Care Med 158:S146S153 Karin M, Zg L, Zandi E (1997) AP-1 function and regulation

Hydrogen peroxide priming modulates abiotic oxidative stress tolerance: insights from ROS detoxification and scavenging