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Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression

Additionally, experiments conducted on isolated bovine chondrocytes revealed an upregulation in the production of proteoglycans and collagen, fundamental components of the extracellular matrix essential for cartilage integrity

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It should be stored in a refrigerator (between 2C and 8C or 36F and 46F), away from direct light