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In CKD, uremic toxins (e.g., indoxyl sulfate) synergize with iron overload to suppress GPX4, further enhancing ROS-mediated eryptosis ( 4 The role of eryptosis in patients 4.1 The role of eryptosis in non-dialysis-dependent patients Eryptosis, the programmed death of erythrocytes characterized by PS exposure on the cell membrane, has emerged as a critical contributor to renal anemia in non-dialysis-dependent chronic kidney disease (NDD-CKD), with estimated glomerular filtration rate (eGFR) identified as its key determinant ( r 2 = 0.22) and the NDD-CKD subgroup ( r 2 = 0.10)

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S -THIQ/ R -THIQ interactions are not favored by this mutation, as amine groups are protonated at physiological pH, resulting in electrostatic repulsions with C135R (Fig

To model the inflammatory conditions associated with liver injury, WT and FBXL5 KO cells were treated with lipopolysaccharide (LPS), a ligand for Toll-like receptor 4 (TLR4), to induce IL-6 expression in DC2.4 cells in vitro

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Acidic methanol treatment facilitates matrix-assisted laser desorption ionization-mass spectrometry imaging of energy metabolism