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For glucose metabolism, a common consequence is to induce preferentially utilization of glucose through glycolysis rather than tricarboxylic acid (TCA) cycle (referred as Warburg effect) under aerobic conditions [5, 6]

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This includes adults over age 50, people who follow vegetarian or vegan diets, and patients taking medications such as Metformin

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Methods Ethics statement All experimental procedures involving mice were reviewed and approved by the Columbia University Institutional Animal Care and Use Committee (IACUC)

TJ abnormalities, including claudin-3 loss, are also found in progressive MS, suggesting pathological opening of paracellular channels (250, 251)