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The prodrug designing through this technique should be chemically stable under targeted physiological conditions and must have good pharmacodynamic and pharmacokinetic responses as well as the prodrugs substrates must have properties for activation when it attached on enzyme under targeted physiological environment

doi: 10.1007/s40618-016-0453-5 72 SimacPPerkovicDBozicIBilopavlovicNMartinovicDBozicJ