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Collectively, our data provides mechanistic insight into the behaviour of Cagri as a dual CTR and AMYR agonist peptide

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Single KOs were maintained through heterozygous breeding, while double KOs were bred homozygously and WT mice were age-matched controls

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Preclinical and clinical studies have demonstrated its efficacy in reducing body weight both as a monotherapy and in combination with GLP-1 receptor agonists such as semaglutide, highlighting its potential as a next-generation therapeutic agent for obesity and metabolic syndrome management