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A 2023 systematic review concluded benefits are promising but more, larger trials are needed

Cancer Biol Med 13(1):120135 Zhao H, Ming T, Tang S, Ren S, Yang H, Liu M et al (2022) Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

NNMT as Target (Kraus et al., 2014): NNMT knockdown in white adipose tissue and liver protected against diet-induced obesity by increasing cellular energy expenditure

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But it is unprecedented for a drug to be put on the pathway to widespread adoption in this manner instead of having to go through the more arduous and evidence-based FDA drug approval process, experts say