Despite this apparent metabolic redundancy, there is also evidence that the method of nutrient consumptionparticularly, bolus versus gradual fructose feedingresults in differential ACLY and ACSS2 utilization in the liver
doi: 10.1186/1471-2261-7-20, 150

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This study was conducted to review the melatonin potential to prevent the pathogenesis of nephrotoxicity induced by important nephrotoxic drugs
Other strategies can involve "rest periods" or "drug holidays" during which the patient abstains from L-DOPA for a short time
In conclusion, the Authors suggest the administration of up to 2 consolidation cycles with an intermediate dose of cytarabine after induction therapy in patients in CR who are not eligible for transplantation