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M., Kim, D

It has been reported that AGEs adversely affect several processes by two primary mechanisms: Directly through trapping and cross-linking of proteins, and indirectly by binding to specific receptors for AGE on the surface of various cells

Ghorbi M, Rashidi M, Olapour A, et al

Human studies typically involve a small number of sufferers or those who are pregnant

The age-related decline in neuromodulators, neurotransmitters, and glutathione levels may account for the diminished cognitive benefits of caffeine and paraxanthine in older animals