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For more clarification, we can compare all the scenarios for all channels based on the type of the modulation schemes as follows

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That doesnt mean the question is unanswerable it means the evidence has limits you need to understand before making any decisions

Lancet 391 (10137), 23562367

Sclerosis of interlobular and arcuate arteries, tubular atrophy and glomerular scarring are late features of RN [56, 57]