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The activity and stability of key enzymes in the SSP are precisely regulated by transcription factors (such as c-Myc, HIF-1, and NRF2), epigenetic modifications (including m5C and m6A), and post-translational modifications (such as methylation, ubiquitination, and deacetylation)

The cells were cultured in F-12 K medium (Sigma-Aldrich, St

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The Osteoarthritis Research Society International (OARSI) scoring was obtained on the basis of previous studies 29

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