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Clinical trials have established the proof-of-concept for intrathecal ASO therapy, exemplified by tofersen for SOD1-ALS, which achieved accelerated approval based on biomarker reduction despite not meeting the primary clinical endpoint in its phase 3 VALOR trial (8, 43, 44)

Lehrer, R

[57], both healthy and OVA-sensitized mice on a vitamin-D-deficient diet had higher histamine and TNF levels in their serum compared to animals receiving vitamin-D-sufficient or supplemented chow

& Escobar, J

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Skeletal Radiol 2012