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Selenium, as a constituent of antioxidant enzymes like glutathione peroxidase, can mitigate oxidative stress 20,21,22

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Th17 cells, whose proliferation is closely connected to gut dysbiosis, produce IL-17 A and GM-CSF, which not only activate microglia but also damage the BBB by acting on endothelial IL-17RA, resulting in a self-reinforcing permeability loop

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