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Description

Applications of fluorine in medicinal chemistry

A representative drug, liproxstatin, a lipophilic radical-trapping antioxidant (RTA) that helps prevent lipid peroxidation

The M1 phenotype, stimulated by lipopolysaccharide (LPS) and interferon- (IFN-), was used as a positive control, whereas the M2 phenotype, induced by interleukin-4 (IL-4), functioned as a negative control

The altered fluorescence intensity revealed itaconate fluctuations under inflammatory conditions, making it a powerful tool for imaging itaconate with temporalspatial resolution in living macrophages