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Zhang CE, Wei W, Liu YH et al (2009) Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain

The data suggest that angiogenic effects of OxPLs are mediated by several signal transduction pathways including unfolded protein response, 35,36 transcription factor NRF2, 32,37 microRNAs (miR-663 35 and miR-155 32 ), as well as protein kinase CK2

In a previous study, researchers treated mice with a vitamin D-enriched diet and observed an increase in Klotho expression (112)

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The serine deprivation-dependent induction is regulated by the activating transcription factor 4 (ATF4) and can be reversed by the addition of glycine and serine, but not by other amino acids like leucine or cysteine ( 2.2 CHAC1 regulation through the ATF4-CHOP axis during ER stress The link between amino acid depletion and ATF4 directly connects to a major upstream regulator of CHAC1: the ER stress pathway

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