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Initial observations described no differences in endothelial-dependent dilation between habitual users of combustible tobacco products, users of electronic cigarettes, dual users, and non-users [116, 120], although lower endothelial cell nitric oxide production has been identified in users of ENDS and users of combustible tobacco products when compared to non-users [120]

According to Philip Morris International's 2018 annual report, "The tobacco union requested a stay of the enforcement of the ingredient ban while the appeal is pending." The Brazilian government won the court case in February 2018, though as of 2025, this ban still remains to be implemented

Global Status Report on Noncommunicable Diseases

The carton is designed for bulk purchasing and convenience

The soft tip lends itself to a very soft vape, while it has a slightly stronger throat hit with the included standard drip tip