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Figure 4 Figure 5 3.4 Barriers to diagnosis and registry development A significant proportion of PD patients in LMICs remain undiagnosed or misdiagnosed, especially in rural and low-resource settings

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Recent experimental work also supports these findings

Wu RY, Liu AY, Sio TT, Blanchard P, Wages C, Amin MV, Gunn GB, Titt U, Ye R, Suzuki K, Gillin MT, Zhu XR, Mohan R , Frank SJ

miRNA-130b-5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression

Nerve growth factor protects retinal ganglion cells related to inhibiting endoplasmic reticulum stress by inhibiting IRE1-JNK-CHOP signaling pathway

The endocannabinoid system maintains the HPA axis in a stable basal state and attenuates the stress response, thereby allowing recovery of homeostasis (Surkin et al., 2018)