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In studies, several HCC cell lines, including HepG2, Huh7, HLE, HLF, and SNU, show enhanced proliferation in response to ROS induction

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In the kynurenine pathway, an action of pro-inflammatory cytokines in microglia is to increase the action of the enzymes that participate in the pathway of quinolinic acid (QA), a neurotoxic metabolite

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Int J Mol Sci 18(5):1053 Seifman MA et al (2014) Measurement of serum melatonin in intensive care unit patients: changes in traumatic brain injury, trauma, and medical conditions