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Thus, since iron levels in macrophages may drive cholesterol efflux, targeting macrophages environment manipulating iron levels and/or iron metabolism-related molecules could interfere with the generation of foam cells and the development of atherosclerosis

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Importantly, pharmacological GCL inhibition hindered lymphoma growth in female -MYC mice, suggesting that this treatment holds promise as a therapeutic strategy for female lymphoma/leukemia patients

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The right choice depends on what you value most: maximum efficacy with managed side effects, or minimal disruption with limited outcomes