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J Carbohydr Polym

Furthermore, it should be noted that three recently discovered dimeric indole alkaloids namely 17-deacetoxycyclovinblastine, 14,15-didehydrocyclovinblastine, and 17-deacetoxyvinamidine along with five established compounds (vinamidine, leurosine, catharine, cycloleurosine, and leurosidine) exhibited in vitro viability inhibition against the human breast cancer cell line MDA-MB-231 with an inhibitory concentration ranging from 0.73 to 10.67 M (44)

Funding This work was supported by a Grant from the Ministry of Science and Technology, Taiwan (MOST 108-2622-B-006-003-CC1

ROS not only act as direct mediators of oxidative damage but also serve as signaling molecules that activate inflammatory pathways such as NF-B and AP-1, promoting the expression of pro-inflammatory factors 32

In segment (a) , inhibition of hexokinase (or its prevention from docking VDAC) would be insufficient because of the provision of glucose-6-phosphate through galactose, ribose, and glyceraldehyde-3-phosphate