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1 Introduction 1.1 Bile acids: key immuno-metabolic signals sculpted by the gut microbiota Bile acids (BAs), beyond their traditional role in lipid digestion, are now recognized as pleiotropic signaling molecules crucial for metabolic and immune homeostasis ( 1.2 The tumor immune microenvironment and dysregulation of the microbiota-bile acid axis in cancer Before delving into the pathological consequences of a dysregulated microbiota-BA axis, it is important to first establish its fundamental role in maintaining homeostasis

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This challenge underscores the importance of investigating specific ferroptosis markers in lung cancer cells [157]

GRB2 consists of one SH2 domain and two SH3 domains, of which the SH3 domain is capable of binding SOS1, a kind of GEF