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found that nicotine can mediate the pyroptosis of aortic endothelial cells and exacerbate the formation of atherosclerotic plaques by constructing an ApoE-/- mouse atherosclerosis model (93)

While not listed as a direct adverse effect in FDA prescribing information, this cold sensitivity appears linked to the medication's weight loss effects rather than direct temperature regulation changes

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.de Baat A., Trinh B., Ellingsgaard H., Donath M.Y

We may request approval from your GP or specialist to ensure IV therapy is safe and appropriate for you

Rehabil 2022, 4 (2), e393e402

In short, the feasibility and efficacy of MSCs in the treatment of radiation-induced fibrosis in humans are difficult to be confirmed in the short term