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Hyperactivation of STAT3 enhances the production of proinflammatory cytokines, including interleukin (IL)-6 and IL-23, promoting the senescence-associated secretory phenotype (SASP) and sustaining inflammatory signaling

Under physiological conditions, a healthy gut microbiota and an intact intestinal barrier are critical for establishing immune tolerance ( The tumor immune microenvironment (TIME), a dynamic ecosystem of cancer cells, stromal cells, ECM, and diverse immune cells, profoundly shapes tumor progression and therapeutic responses ( A pivotal mechanism linking gut dysbiosis to pro-tumorigenic inflammation is the translocation of microbial components, most notably lipopolysaccharide (LPS), across a compromised intestinal barrier ( Beyond TLR-dependent microbial sensing, the NF-B pathway serves as a critical signaling hub that integrates diverse pro-tumorigenic stimuli within the TIME

Luo J, Pan S, Luo J, Wang L, Yin J, Zhao H, et al

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5.2 Vitamin C and ASD Vitamin C is a powerful antioxidant capable of counteracting and eliminating ROS produced during metabolic processes (Figueroa-Mndez and Rivas-Arancibia, 2015)

it's taken dissolved in water