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This pathway was also investigated in RAW264.7 cells, where IFN- production, accompanied by STAT-1 phosphorylation, was detected 6 hours after LPS exposure

Pediatrics 117 , 16731679 (2006)

The identification of identical human and murine mutations at position A7 suggests that the pathogenesis of neonatal DM in these patients is likewise similar to that of the Akita mouse

These changes reduce production of proinflammatory cytokines such as IL-17 and promote anti-inflammatory functions in immune cells, including microglia (101)