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It can also occur during post-cleavage purification in TFA/H 2 O/ACN mixtures, or if lyophilized peptides are stored at mildly acidic pH (5-6)

But do a patch test first to avoid irritation problems

doi: 10.3389/fgene.2022.920273 54 ZhaoCYuYYinGXuCWangJWangLet al

Enrichment analysis of proteins whose abundance increased at least 2 times in therapy-induced secretomes from all cancer cell lines revealed a predominant association with splicing regulation (Fig