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This reaction is catalyzed by specific gut bacteria such as Eggerthella lenta rK3, which converts EC and related catechins into 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl) propan-2-ol through C-ring opening under anaerobic conditions ( Flavonifractor plautii aK2, which along with E

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Thiolate anions are better nucleophiles than are alkoxy anions (see Section 11.5, pages 389-394 of the textbook)