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& Domingues, L

Data availability The data in this study will be made publicly available according to publication date in the Gene Expression Omnibus (GEO) under accession no

For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51

This is one reason weight loss can sometimes result in heavy metal detoxing, as fat cells shrink and release dormant toxins

ALA: Alpha-lipoic acid (ALA) is naturally found in the mitochondria and is needed for normal metabolism

Other adverse effects include thrombocytopenia and cardiovascular complications such as congestive heart failure and hypotension [53]