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Lipofuscin accumulates within lysosomes as a result of incomplete degradation of cellular components, and this phenomenon is considered part of normal aging [10, 14]

Similarly, this approach might be useful in FRDA since H 2 O 2 is a critical pathogenic agent associated to frataxin deficiency (Anderson et al., 2008)

Association between abnormal lipid metabolism and Alzheimers disease: new research has revealed significant findings on the APOE4 genotype in microglia