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Supplementary material The Supplementary Material for this article can be found online at: References 1 AkbulutT.CinarV.AvcuE

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PIWIpiRNA pathway defects map mechanistically to meiotic arrest and non-obstructive azoospermia (NOA), with tissue-level confirmation from human testicular studies

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Without adequate copper availability through GHK-Cu, newly formed collagen fibers cannot achieve proper structural cross-linking, making them vulnerable to rapid degradation by metalloproteinases